The latest prescription weight loss craze is a once-weekly injection of Wegovy (semaglutide) at a cost of over $1,400 per month. Wegovy is a higher dosage version of Ozempic, a drug also produced by big pharma giant Novo Nordisk A/S that was approved for the treatment of type 2 diabetes in 2017. Wegovy was approved for weight loss by the United States FDA in 2021.
Semaglutide works as a GLP-1 receptor agonist, which means that it acts like a compound that we make in our body known as human glucagon-like peptide-1 (GLP-1). Semaglutide is chemically 94% identical to human GLP-1. But it behaves much differently (discussed below) and that creates potential problems.
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