Tag Archives: proteolytic enzymes

December 22nd, 2010

Healing Power of Proteolytic Enzymes

pineappleKey to Powerful Anti-Inflammatory & Immune Support

Proteolytic enzymes are indicated in inflammatory conditions and to support the immune system. Proteolytic enzymes (or proteases) refer to the various enzymes that digest (break down into smaller units) protein. These enzymes include the pancreatic proteases chymotrypsin and trypsin, bromelain (pineapple enzyme), papain (papaya enzyme), fungal proteases, and Serratia peptidase (the “silk worm” enzyme). Preparations of proteolytic enzymes have been shown to be useful in the following situations:

  • Cancer
  • Digestion support
  • Fibrocystic breast disease
  • Food allergies
  • Hardening of the arteries (atherosclerosis)
  • Hepatitis C
  • Herpes zoster (shingles)
  • Inflammation, sports injuries and trauma
  • Pancreatic insufficiency
  • Multiple sclerosis
  • Rheumatoid arthritis and other
  • Sinusitis, asthma, bronchitis, and autoimmune disorders chronic obstructive pulmonary disease

How do the proteolytic enzymes help autoimmune conditions like rheumatoid arthritis?

The benefits in some inflammatory conditions appears to be related to helping the body breakdown immune complexes formed between antibodies produced by the immune system and the compounds they bind to (antigens). Conditions associated with high levels of immune complexes in the blood are often referred to as “autoimmune diseases” and include such diseases as rheumatoid arthritis, lupus, scleroderma, and multiple sclerosis. Higher levels of circulating immune complexes are also seen in ulcerative colitis, Crohn’s disease, and AIDS. 4-6

How are Proteolytic enzymes used in cancer therapy?

Proteolytic enzymes have a long history of use in cancer treatment. In 1906, John Beard, a Scottish embryologist, reported on the successful treatment of cancer using a pancreatic extract in his book The Enzyme Treatment of Cancer and its Scientific Basis. Proteolytic enzymes have been promoted by numerous alternative cancer practitioners for many years, but most recently by Nicholas Gonzalez, M.D., who is evaluating the benefit of proteolytic enzymes in patients with advanced pancreatic cancer in a large-scale study, funded by the National Institute of Health’s National Center for Complementary and Alternative Medicine, with collaboration from the National Cancer Institute. This larger trial is a follow-up to a smaller study that showed dramatic improvements in these patients.

How do Proteolytic enzymes work to fight cancer?

Once absorbed the body prevents digestion of proteins in the blood and other body tissues producing antiproteases. The production of these antiproteases is critical to the mechanism of action of proteolytic enzymes. These antiproteinases block the invasiveness of tumor cells as well as prevent the formation of new blood vessels (angiogenesis). Proteolytic enzymes exert a number of other interesting anticancer mechanisms including the inhibition of metastasis (the spread of cancer) and the enhancement of the immune response. 1

What clinical research has been done with proteolytic enzymes in cancer?

The clinical research that currently exists on proteolytic enzymes suggests significant benefits in the treatment of many forms of cancer.2 Specifically these studies have shown improvements in the general condition of patients, quality of life, and modest to significant improvements in life expectancy. Studies have consisted of patients with cancers of the breast, lung, stomach, head and neck, ovaries, cervix, and colon; lymphomas and multiple myeloma. These studies involved the use of proteolytic enzymes in conjunction with conventional therapy (surgery, chemotherapy and/or radiation) indicating that proteolytic enzymes can be used safely and effectively with these treatments. Proteolytic enzymes are not recommended for at least two days before or after a surgery as they may increase the risk of bleeding. Proteolytic enzymes have been shown to be quite helpful in speeding up post-surgical recovery and relieving a complication of surgery and radiation known as lymphedema. (SEE TABLE 1-2)

What other conditions might proteolytic enzymes be helpful for?

The list of conditions benefited by pancreatic enzyme supplementation seems to be growing all the time. For example, one potential use is in the treatment of viral related illness including hepatitis C and herpes simplex infections. For example, in one study in the treatment of herpes zoster (shingles) an orally administered proteolytic enzyme preparation was more effective than the standard drug therapy (acyclovir).8 In a study in patients with hepatitis C, proteolytic enzymes were shown to be slightly superior to alphainterferon in improving laboratory values and symptoms.9 Proteolytic enzymes also appear to be quite helpful in recovery from surgery, fibrocystic breast disease, acute and chronic sinusitis and bronchitis, and chronic obstructive pulmonary disease and asthma.10-13

Can taking proteolytic enzymes actually improve digestion?

Yes, in fact, using enzyme preparations to support proper digestive function is used in conventional
medicine in cases of pancreatic insufficiency and cystic fibrosis (a rare inherited disorder). Pancreatic insufficiency is characterized by impaired digestion, malabsorption, nutrient deficiencies, and abdominal discomfort.

Are proteolytic enzymes actually absorbed?

Yes. One of the outdated arguments against the effectiveness of orally administered proteolytic enzymes was that they either got digested or they were too large to be absorbed. Absorption studies with the various proteolytic enzymes have confirmed that they are absorbed intact. In fact, they appear to be actively transported across the gut wall.3 Since stomach acid can destroy proteolytic enzymes, the best formulas are “enteric coated” – meaning that the pills have a coating around them to prevent the pill from being broken down in the stomach. An enteric-coated pill passes into the small intestine, where due to the pH change it will break down there.

Do the proteolytic enzymes digest blood proteins?

NO! There are special factors in the blood that block the enzymes so that they do not digest blood proteins.

What proteolytic enzyme product do you recommend?

In order to get the most out of proteolytic enzymes it is essential to use a high quality product at an adequate dosage. To judge the quality of an enzyme preparation it is important to know what you are looking for. Most of the proteolytic enzymes have well established guidelines developed by the United States Pharmacopoeia (USP) or the Food Chemical Codex (FCC). The product that I recommend contains the following ingredients per enteric-coated tablet. It is more than twice as potent as other popular preparations:

Pancreatin(8X) 200 mg.
Papain (30,000 USP/mg) 120 mg.
Peptizyme SP (200,000 SPU/g) 52 mg.
Bromelain (1,200 MCU/g) 50 mg.

Pancreatin refers to pancreatic enzyme preparations prepared from fresh hog pancreas. The two primary proteases of pancreatin are chymotrypsin and trypsin (also available from ox bile). Papain and bromelain are proteolytic derived from papaya and pineapple, respectively. Peptizyme SP (a special serrapeptase) is derived from a bacteria that resides in the intestines of silk worms. It is also called “silk worm” enzyme as it is the enzyme used to breakdown the cocoon of the silk worm.

The Miracle Enzyme

Dr. Hans Nieper, a legendary medical doctor known for his extensive use of proteolytic enzymes, called serrapeptase the “Miracle Enzyme.” Dr. Nieper used the enzyme primarily to open up clogged arteries supplying the brain. This enzyme is more powerful than the pancreatic enzymes chymotrypsin and trypsin. It has been used in Europe and Japan for over 25 years. As evident in Table 1, good clinical results have been demonstrated in clinical trials. In addition to its general anti-inflammatory effects, it is particularly beneficial in fibrocystic breast disease as well as upper respiratory tract conditions like sinusitis, bronchitis, asthma, and chronic obstructive pulmonary disease due to its ability to improve the structure and function of the mucus lining.10-13

Are proteolytic enzymes preparations safe?

Proteolytic enzymes are generally well-tolerated and are not associated with any significant side effects. Even in people with presumably normal pancreatic function, taking proteolytic enzymes produced no untoward side effects nor did it reduce the capacity for these subjects to produce their own pancreatic enzymes.14 However, my recommendation is to utilize these preparations only when there is apparent need.

Although no significant side effects have been noted with any of the proteolytic enzymes, allergic reactions may occur (as with most therapeutic agents). Pancreatic enzymes should not be used by anyone allergic to pork; bromelain should not be used in anyone allergic to pineapple; and papain should not be used in anyone sensitive to papaya.

References

1. Rubinstein E, et al.: Antibacterial activity of the pancreatic fluid. Gastroenterol 1985;88:927-32.
2. Ambrus JL, et al.: Absorption of exogenous and endogenous proteolytic enzymes. Clin Pharmacol Therapy 1967;8:362-8.
3. Kabacoff BB, et al.: Absorption of chymotrypsin from the intestinal tract. Nature 1963;199:815-7.
4. Martin GJ, et al.: Further in vivo observations with radioactive trypsin. Am J Pharm 1964;129:386-92.
5. Avakian S: Further studies on the absorption of chymotrypsin. Clin Pharmacol Therap 1964;5:712-5.
6. Liebow C and Rothman SS: Enteropancreatic circulation of digestive enzymes. Science 1975;189:472-4.
7. Oelgoetz AW, et al.: The treatment of food allergy and indigestion of pancreatic origin with pancreatic enzymes.
Am J Dig Dis Nutr 1935;2:422-6.
8. Carroccio A, et al.: Pancreatic enzyme therapy in childhood celiac disease. A double-blind prospective randomized
study. Dig Dis Sci 1995;40:2555-2560.
9. Innerfield I: Enzymes in Clinical Medicine. McGraw Hill, New York, 1960.
10. Mazurov VI, et al. Beneficial effects of concomitant oral enzymes in the treatment of rheumatoid arthritis. Int J
Tiss React 1997;19:91.
11. Ransberger K: Enzyme treatment of immune complex diseases. Arthritis Rheuma 1986;8:16-9.
12. Steffen C, et al.: Enzyme therapy in comparison with immune complex determinations in chronic polyarteritis.
Rheumatologie 1985;44:51-6.
13. Ransberger K and van Schaik W: Enzyme therapy in multiple sclerosis. Der Kassenarzt 1986;41:42-5.
14. Gonzalez NJ and Isaacs LL: Evaluation of pancreatic proteolytic enzyme treatment of adenocarcinoma of the
pancreas, with nutrition and detoxification support. Nutr Cancer 1999;33:117-24.
15. Leipner J and Saller R: Systemic enzyme therapy in oncology: effect and mode of action. Drugs. 2000;59:769-
80.
16. Kleine MW, Stauder GM and Beese EW:The intestinal absorption of orally administered hydrolytic enzymes
and their effects in the treatment of acute herpes zoster as compared with those of oral acyclovir therapy.
Phytomedicine 1995;2:7-15.
17. Kabil SM and Stauder G: Oral enzyme therapy in hepatitis C patients. Int J Tiss React 1997;19:97-8.
18. Schneider, MU, Knoll-Ruzicka ML, Domschke S, et al: Pancreatic enzyme replacement therapy: Comparative
effects of conventional and enteric-coated microspheric pancreatin and acid-stable fungal enzyme preparations
on steatorrhea in chronic pancreatitis. Hepatogastroenterol 1985;32:97-102.
19. Friess H, et al.:Influence of high-dose pancreatic enzyme treatment on pancreatic function in healthy volunteers.
Int J Pancreatol 1998;23:115-23.

December 21st, 2010

Natural Support During Chemotherapy

For many people the very thought of chemotherapy evokes frightening images of debilitating nausea, vomiting, diarrhea and weakness. However, newer medications have made most chemotherapy regimens much better tolerated than in the past. Nonetheless, chemotherapy can produce a wide range of undesirable side effects. Which side effects will occur has much to do with the type of chemotherapy, the dosage and timing of the treatments, the general health of the patient and the history of prior chemotherapy.

One of the problems with chemotherapy is that it is active against all dividing cells whether cancerous or not. This means that cells lining the intestines, in the bone marrow and in the hair follicles, all of which are also continuously dividing, will also be damaged by chemotherapy. Fortunately, there are natural products that can be used to protect against the damaging effects of chemotherapy while simultaneously increasing the effectiveness of the chemotherapy. The natural measures that I am recommending are definitely worth incorporating into your cancer treatment plan and may mean the difference of life or death.

Along with some basic dietary guidelines, there are five key supplements that can be used to support any form of chemotherapy or radiation.

  • A high potency multiple vitamin and mineral
  • Regular consumption of “greens” drinks
  • Maitake D- or M,D-fraction
  • Proteolytic enzymes
  • Curcumin

In addition, it is important to take coenzyme Q10 if you are taking doxorubicin (Adriamycin) or any other chemotherapy agent known to damage the heart. What are the general dietary guidelines to follow? Because of the problem of nausea and vomiting sometimes caused by cancer itself, as well as many chemotherapy agents and/or radiation therapies, many cancer patients develop anorexia – the loss of appetite or desire to eat. This situation is not good at all because it can lead to a condition known as cancer “cachexia” – a wasting syndrome characterized by weakness and a noticeable continuous loss of weight, fat, and muscle. It is estimated that roughly 40 percent of cancer patients actually die of malnutrition rather than their disease itself. The importance of high quality nutrition in the battle against cancer cannot be overstated.

Cancer patients who have higher nutritional status are better able to tolerate cancer therapy and its side effects. A person on chemotherapy with poor nutritional status can lead to progressive wasting, weakness, and lower resistance to infection that can sometimes end fatally.

The following dietary suggestions can help improve nutritional status in cancer patients:

  1. Eat small frequent meals (every 1-2 hours).
  2. Drink a high-protein smoothie containing 20 to 30 grams of whey protein twice daily.
  3. Get a juice machine and drink 18 to 24 ounces of fresh fruit or vegetable juice daily.
  4. Use extra seasonings, spices, and flavorings, but avoid flavorings that are very sweet or very bitter. A higher sensitivity to the taste of food may cause them to taste flavorless or boring.
  5. Eat soft or moist foods while avoiding hard, dry foods.
  6. Take small bites and chew completely.
  7. Drink at least 48 ounces of water daily in addition to the 18 to 24 ounces of fresh fruit or vegetable juice.

What do you mean by regular consumption of  “greens” drinks?

Greens drinks is the term that we are using to describe green tea and a number of commercially available products containing dehydrated barley grass, wheat grass, or algae sources such as chlorella or spirulina that are then “rehydrated” by mixing with water. The product that I recommend, Enriching Greens®, is packed full of phytochemicals, especially helpful in fighting against cancer. Greens drinks should not be used in patients taking coumadin (Warfarin) – a drug that blocks blood clotting by interfering with the actions of vitamin K. Since greens drinks can be a good source of vitamin K, it is important for people taking coumadin to avoid these drinks.

Should antioxidants be avoided during chemotherapy treatments?

One of the most controversial recommendations to support chemotherapy (as well as radiation therapy) is the recommendation to use antioxidant nutrients during the active phase of the treatment. While there is little concern with using antioxidant nutrients after the completion of a course of chemotherapy or radiation treatment the concern that many oncologists have is that antioxidant nutrients will interfere with the effectiveness of conventional therapies. Is this fear valid?

According to many experts, the answer is no.1,2 Dr. Kedar Prasad and his colleagues at the Center for Vitamins and Cancer Research at the University of Colorado Health Science Center’s Department of Radiology in Denver are among the most knowledgeable experts in this field. Dr. Prasad has stated that the concerns over the use of high dosage antioxidants during chemotherapy and radiation “are not valid.” Dr. Prasad feels that “based on results of our studies and others, we have proposed a hypothesis that supplementation with high doses of multiple antioxidant vitamins, together with diet modification and lifestyle changes, may improve the efficacy of standard and experimental cancer therapies by reducing their toxicity on normal cells and by enhancing their growth-inhibitory effects on cancer cells.”

The bottom line is that in addition to countless animal studies, the majority of human studies have shown patients treated with antioxidants during chemotherapy and/or radiation tolerate standard treatment better, have a better quality of life, and most importantly, live longer than patients receiving no supplements. For example, the conclusion in a study in patients with small-cell lung cancer using combination chemotherapy of cyclophosphamide, Adriamycin (doxorubicin), and vincristine with radiation and a combination of antioxidants, vitamins, trace elements, and fatty acids was that the nutritional support significantly prolonged the survival time of patients.3

But, my oncologist told me scientific evidence shows that antioxidants interfere with chemotherapy, what should I do?

When oncologists cite “scientific evidence” that antioxidants interfere with chemotherapy and radiation, they tend to ignore the fact that the majority of these sorts of studies show predominantly beneficial effects. The scientific evidence that oncologists often refer to consist primarily of animal studies where they fed animals (usually via an injection into the intestines) dosages of an antioxidant that far exceed the amount normally recommended or in vitro (test tube) studies that used concentrations of antioxidants not achievable in living systems.

For example, when vitamin E is given to mice at dosages not likely to be achieved with normal supplementation in humans (e.g., dosage greater than 35,000 IU) it can reduce the effectiveness of radiation therapy.4 However, based upon human and animal studies, vitamin E at commonly used dosages does not interfere with radiation therapy or chemotherapy and actually appears to enhance the success of these treatment.5,6 The same can be said with CoQ10 and many other antioxidants. The only real exception is N-acetylcysteine (NAC) – a derivative of the naturally occurring amino acid cysteine. NAC has not been shown to significantly effect treatment outcome and carries with it some risk of inhibiting chemotherapy agents (e.g., cisplatin). 7,8

So, I do not recommend it being used during active treatment with any chemotherapy agent. After chemotherapy is over, then NAC may be of benefit in reversing any kidney or nerve damage. As far as what to do, I think that it is extremely important to develop a relationship with an oncologist or cancer treatment center that you have confidence in and that you can communicate with. That may seem like a difficult task, but it can be done. I encourage you to discuss all supplement use with your physician. If your physician is not familiar with the scientific literature that supports the use of antioxidants during chemotherapy and radiation treatments, then I would refer them to the review article written by Dr. Kedar Prasad and his colleagues “High Doses of Antioxidant Vitamins: Essential Ingredients in Improving the Efficacy of Standard Cancer Therapy,” published in the Journal of the American College of Nutrition (see reference #1). Hopefully, when your oncologist becomes more familiar with the facts they will support your use of the recommendations I am making here.

Why is it important to take a high potency multiple vitamin and mineral if you are on chemotherapy?

Since the immune system requires a constant source of virtually every nutrient, it only makes sense that a high-potency multiple-vitamin and mineral formula is the first step in supporting the immune system with nutritional supplementation in patients on chemotherapy. Deficiencies of virtually any nutrient can result in significantly impaired immune function especially deficiencies of vitamins C, E, A, B6, B12, and folic acid.

Minerals that are especially important are zinc and selenium. The multiple vitamin and mineral formulas that I recommend, the MultiStart™ products from Natural Factors, are designed to meet the different nutritional needs of different ages and gender. These formulas contain not only gender and age specific levels for vitamins and minerals, but also appropriate digestive factors and herbal extracts based on gender and/or age.

What is Maitake D or M, D-fraction?

The maitake mushroom (Grifola frondosa) is the source of immune enhancing compounds that are being shown to offer significant health benefits. In the early 1980s, Dr. Hiroaki  Nanba of Japan was researching the immune enhancing properties of mushrooms when he came to the conclusion that maitake extracts demonstrated more pronounced antitumor activity in animal tests than other mushroom extracts. One of the key benefits to maitake is the ability to be quite effective when given orally. In contrast, the other mushrooms Dr. Nanba studied such as shitake were only effective when injected into the bloodstream.

In 1984, Dr. Nanba identified a fraction of maitake that possessed a significant ability to stimulate white blood cells known as macrophages (literal translation “big eaters”). These specialized white blood cells phagocytize, or engulf, foreign particles including cancer cells, bacteria, and cellular debris. Dr. Nanba termed his discovery maitake D-fraction. Further purification of the D-fraction yielded the M,D-fraction (U.S. Patent #5,854,404), which is even more bioactive than the D-fraction.

Maitake beta-glucan fractions appear to help reduce the side effects of conventional chemotherapy (and radiation) while at the same time enhancing its effectiveness. In 1994, a group from China published findings from a pilot study on 63 cancer patient reporting a total effective rate against solid tumors at higher than 95 percent and the effective rate against leukemia higher than 90 percent.9 In a preliminary study conducted by Dr. Nanba, 165 patients with advanced cancer were given maitake extract. 10

In the patients who were also on chemotherapy, 90 percent of the patients experienced a reduction in the side effects common to chemotherapy including hair loss, decreased white blood cell counts, nausea, vomiting, and loss of appetite. Maitake was shown to effectively reduce pain levels in 83 percent of the patients. The results were best in breast, lung, and liver cancers. Dr. Nanba reported significant improvement in symptoms or regression of tumors in 73.3 percent of patients with breast cancer, 66.6 percent in lung cancer, and 46.6 percent in liver cancer.

The dosage of maitake extracts is based upon the level of the D- or M,D-fraction. The therapeutic dosage range is based upon body weight, 0.5mg to 1.0 mg for every 2.2 pounds (1 kg) of body weight per day. That translates to a dosage of approximately 35-70 mg of the D- or M,D-fraction. The dosage recommendation for prevention is typically 5 to 15 mg of the D- or M,D-fraction. For best results take 20 minutes before meals or on an empty stomach.

What are proteolytic enzymes?

Proteolytic enzymes (or proteases) refer to the various enzymes that digest (break down into smaller units) protein. These enzymes include the pancreatic proteases chymotrypsin and trypsin, bromelain (pineapple enzyme), papain (papaya enzyme), fungal proteases, and Serratia peptidase (the “silk worm” enzyme). Proteolytic enzymes have a long history of use in cancer treatment. The clinical research that currently exists on proteolytic enzymes suggests significant benefits in the treatment of many forms of cancer. Clinical studies have shown improvements in the general condition of patients, quality of life, and modest to significant improvements in life expectancy. 11

Studies have consisted of patients with cancers of the breast, lung, stomach, head and neck, ovaries, cervix, and colon; and lymphomas and multiple myeloma. These studies involved the use of proteolytic enzymes in conjunction with conventional therapy (surgery, chemotherapy and/or radiation) indicating that proteolytic enzymes can be used in conjunction with these conventional therapies. Because the animal and vegetarian-derived proteolytic enzymes have slightly different effects, I recommend using Zymactive™ – a high potency proteolytic enzyme complex that features a wide range of powerful proteolytic enzymes. I recommend starting at the lower dosage level of one tablet 15 minutes before meals three times per day and increase gradually weekly increments to the full dosage of three tablets three times daily. Note: taking too much of any proteolytic enzyme can lead to gastrointestinal upset and/or diarrhea.

What is curcumin and how does it help the cancer patient?

Curcumin is the yellow pigment of turmeric (Curcuma longa) – the chief ingredient in curry. It has demonstrated significant activity in many experimental and clinical studies involving inflammation and anticancer properties. It exerts a complex set of actions beneficial for the prevention and treatment of cancer. The anticancer effects of turmeric and curcumin have been demonstrated at all steps of cancer formation: initiation, promotion, and progression. 12 The protective effects of curcumin are only partially explained by its direct antioxidant effect. Other anticancer effects noted include the ability to: inhibit the formation of cancer-causing nitrosamines; enhance the body’s levels of anticancer compounds such as glutathione; promote the proper detoxification of cancer-causing compounds by the liver; and prevent the over expression of the enzyme cyclo-oxygenase 2 (COX-2).

This enzyme produces pro-inflammatory and cancer promoting derivatives of essential fatty acids (prostaglandins of the 2 series). Curcumin has demonstrated significant antitumor results in a number of experimental models of prostate, breast, skin, colon, stomach and liver cancers. Its effects are thought to be the result of several mechanisms:

  • Inhibiting angiogenesis. The growth of tumors is dependent on developing new blood vessels to feed it.
  • Inhibiting epidermal growth factor (EGF) receptor sites. About two-thirds of all cancers overproduce EGF receptor sites thereby increasing the sensitivity of the cancer cells to this substance that stimulates cellular proliferation.
  • Inhibiting fibroblast growth factor. (BGF). This growth factor promotes angiogenesis – the formation of new blood vessels to feed the growing tumor.
  • Inhibiting nuclear factor kappa beta (NF-kb). Many cancers overproduce this growth factor to escape arrest of cellular proliferation.
  • Increasing apoptosis (cellular suicide) of cancer cells.
  • Inhibiting enzymes within tumor cells that promote growth.

The recommended dosage for curcumin is 200–400mg three times a day.

Why do you recommend coenzyme Q10 for people taking doxorubicin?

Doxorubicin is especially harmful to the heart and can produce serious damage (cardiomyopathy). In fact, the damage to the heart is often life threatening. A number of studies have shown CoQ10 can prevent the cardiac toxicity associated with doxorubicin without reducing the anti-tumor effect.13,14 For best results, I recommend using Clear Q™ by Natural Factors. In order to enhance the absorption and utilization of CoQ10, some manufacturers have looked to synthetic compounds to enhance the solubility of CoQ10. Instead of following this approach, Natural Factors has chosen to utilize nature instead. Using a patent pending process known as Lipcom® (short for lipid compression), they dissolved CoQ10 in the purest form of natural vitamin E (Clear Base™ Vitamin E; pure, 100% natural d-alpha tocopheryl acetate). The result is that the CoQ10 is biologically enhanced due to increased absorption, utilization, and function.

In a preliminary study, blood levels of CoQ10 at six hours after taking Clear Q produced an increase that was 235 percent greater than the increase achieved with standard CoQ10. Equally impressive is the fact that blood levels of CoQ10 after six hours from taking a loading dosage of Clear Q™ can reach above 2.5 mcg/ml – considered the blood level required in order to achieve consistent results with CoQ10. By providing the CoQ10 dissolved in the vitamin E, absorption is not only enhanced, but also the likelihood that the CoQ10 will remain in its active form. CoQ10 is present in the blood in both oxidized (inactive) and reduced (active) form.

During times of increased oxidative stress or low vitamin E levels, more CoQ10 will be converted to its oxidized (inactive) form. Thus, by providing high levels of pure vitamin E, the biological activity and function of CoQ10 is enhanced. In addition, the CoQ10 actually enhances vitamin E activity as well. For people on doxorubicin, I recommend taking two capsules of ClearQ daily. Like CoQ10, vitamin E prevents the negative effects of doxorubicin without decreasing its therapeutic effects. 6,15

Do you have any special supplement recommendations for breast and prostate cancer?

Yes, there are two other supplements that I recommend to these patients: indole-3-carbinol (I3C) at a dosage of 300 to 400 mg daily and calcium Dglucarate at a dosage of 400 to 1,200 mg daily. IC3 is one of the chief anticancer compounds from cabbage family vegetables. IC3 is especially protective against breast, prostate, and cervical cancer because of a number of actions including an ability to increase the breakdown of estrogen. Preliminary studies have also shown that taking I3C as a dietary supplement significantly increased the conversion of estrogen from cancer-producing forms to non-toxic breakdown products. 16,17

Calcium D-glucarate is also important because it inhibits an enzyme in the gut that interferes with the elimination of excess estrogen.18 One of the key ways in which the body gets rid of estrogen is via attaching glucuronic acid to the estrogen in the liver and then excreting this complex in the bile. Glucuronidase is a bacterial enzyme that uncouples (breaks) the bond between excreted estrogen and glucuronic acid. By inhibiting this enzyme calcium D-glucarate promotes the excretion of estrogen. Another important recommendation in breast or prostate cancer is to consume ground flaxseeds.

Flaxseeds contain an important group of anticancer compounds known as lignans. Flaxseeds are easy to grind with a coffee grinder, food processor or blender. I recommend one or two tablespoons daily added to foods such as hot cereals, salads, or smoothies. While it is better known that flaxseed lignans can prevent and even shrink breast cancer, flaxseed lignans also bind to male hormone receptors and promote the elimination of testosterone. In a study of men with prostate cancer, a low-fat diet (≤ 20% of total calories) supplemented with 30 grams of ground flaxseed (roughly two tablespoons) reduced serum testosterone by 15 percent, slowed the growth rate of cancer cells, and increased the death rate of cancer cells after only 34 days, according to a study conducted at the Duke University Medical Center and Durham Veterans Affairs Medical Center. 19

For more information please get the book “How to Prevent and Treat Cancer with Natural Medicine” co-authored by Dr. Murray.

References

1. Prasad KN, Kumar A, Kochupillai V, Cole WC. High doses of multiple antioxidant vitamins: essential ingredients in improving the efficacy of standard cancer therapy. J Am Coll Nutr 1999;18(1):13-25.
2. Lamson DW, Brignall MS. Antioxidants in cancer therapy; their actions and interactions with oncologic therapies. Altern Med Rev 1999;4(5):304-29.
3. Jaakkola K, Lahteenmaki P, Laakso J, et al.Treatment with antioxidant and other nutrients in combination with chemotherapy and irradiation in patients with small-cell lung cancer. Anticancer Res 1992;12:599-606.
4. Sakamoto K, Sakka M. Reduced effect of irradiation on normal and malignant cells irradiated in vivo in mice pretreated with vitamin E. Br J Radiology 1973;46:538-540.
5. Kagreud A, Peterson HI.Tocopherol in irradiation of experimental neoplasms. Acta Radiol Oncol 1981;20:97-100.
6. Perez Ripoll EA, Rama BN,Webber MM. Vitamin E enhances the chemotherapeutic effects of adriamycin on human prostatic carcinoma cells in vitro. J Urol 1986;136:529-531.
7. Olson RD, Stroo WE, Boerth RC. Influence of N-acetylcysteine on the antitumor activity of doxorubicin. Semin Oncol
1983;10:S29-S34.
8. Roller A,Weller M. Antioxidants specifically inhibit cisplatin cytotoxicity of human malignant glioma cells. Anticancer Res 1998;18:4493-4497.
9. Nanba H. Maitake D-fraction: healing and preventive potential for cancer. J Orthomol Med 1997;12:43-49.
10.Nanba H. Results of non-controlled clinical study for various cancer patients using maitake D-fraction. Explore 1995;6:19-21.
11.Leipner J and Saller R: Systemic enzyme therapy in oncology: effect and mode of action. Drugs. 2000;59:769-80.
12.Li JK, Lin-Shia SY. Mechanisms of cancer chemoprevention by curcumin. Proc Natl Sci Counc Repub China 2001;25(2):59-66.
12.Dorai T, Cao YC, Dorai B, Buttyan R, Katz AE.Therapeutic potential of curcumin in human prostate cancer. III. Curcumin inhibits proliferation, induces apoptosis, and inhibits angiogenesis of LNCaP prostate cancer cells in vivo. Prostate 2001;47(4):293-303.
13.Shaeffer J, El-Mahdi AM, Nichols RK. Coenzyme Q10 and adriamycin toxicity in mice. Res Commun Chem Pathol Pharmacol 1980;29;309-315.
14.Iarussi D, Auricchio U, Agretto A, et al. Protective effect of coenzyme Q10 on anthracyclines cardiotoxicity: control study in children with acute lymphoblastic leukemia and non-hodgkin lymphoma. Molec Aspects Med 1994;15:S207-S212.
15.Sonneveld P. Effect of alpha-tocopherol on the cardiotoxicity of adriamycin in the rat. Cancer Treat Rep 1978;62:1033-1036.
16.Wong GY, Bradlow L, Sepkovic D, et al. Dose-ranging study of indole-3-carbinol for breast cancer prevention. Cell Biochem Supply 1997;28-29:111-6.
17.Bell MC, Crowley-Nowick P, Bradlow HL, et al. Placebo-controlled trial of indole-3-carbinol in the treatment of CIN. Gynecol Oncol 2000;78(2):123-9.
18.Walaszek Z, Szemraj J, Narog M, et al. Metabolism, uptake, and excretion of a D-glucaric acid salt and its potential use in cancer prevention. Cancer Detection Prevention 1997;21:178-90.
19.Demark-Wahnefried W, Price DT, Polascik TJ, et al. Pilot study of dietary fat restriction and flaxseed supplementation in men with prostate cancer before surgery: exploring the effects on hormonal levels, prostate-specific antigen, and histopathologic features. Urology 2001;58(1):47-52.

December 21st, 2010

The Healing Power of Proteolytic Enzymes

Proteolytic enzymes (or proteases) refer to the various enzymes that digest (break down into smaller units) protein. These enzymes include the pancreatic proteases chymotrypsin and trypsin, bromelain (pineapple enzyme), papain (papaya enzyme), fungal proteases, and Serratia peptidase (the “silk worm” enzyme). Preparations of proteolytic enzymes have been shown to be useful in the following situations:

  • Cancer
  • Digestion support
  • Fibrocystic breast disease
  • Food allergies
  • Hardening of the arteries (atherosclerosis)
  • Hepatitis C
  • Herpes zoster (shingles)
  • Inflammation, sports injuries and trauma
  • Pancreatic insufficiency
  • Multiple sclerosis
  • Rheumatoid arthritis and other autoimmune disorders
  • Sinusitis, asthma, bronchitis, and chronic obstructive pulmonary disease

Proteolytic enzymes in cancer therapy

Proteolytic enzymes have a long history of use in cancer treatment. In 1906, John Beard, a Scottish embryologist, reported on the successful treatment of cancer using a pancreatic extract in his book The Enzyme Treatment of Cancer and its Scientific Basis. Proteolytic enzymes have been promoted by numerous alternative cancer practitioners for many years, but most recently by Nicholas Gonzalez, M.D., who is evaluating the benefit of proteolytic enzymes in patients with advanced pancreatic cancer in a large-scale study, funded by the National Institute of Health’s National Center for Complementary and Alternative Medicine, with collaboration from the National Cancer Institute. This larger trial is a follow-up to a smaller study that showed dramatic improvements in these patients.1

What clinical research has been done with proteolytic enzymes in cancer?

The clinical research that currently exists on proteolytic enzymes suggests significant benefits in the treatment of many forms of cancer.2 Specifically these studies have shown improvements in the general condition of patients, quality of life, and modest to significant improvements in life expectancy. Studies have consisted of patients with cancers of the breast lung, stomach, head and neck, ovaries, cervix, and colon; and lymphomas and multiple myeloma. These studies involved the use of proteolytic enzymes in conjunction with conventional therapy (surgery, chemotherapy and/or radiation) indicating that proteolytic enzymes can be used safely and effectively with these treatments. Proteolytic enzymes are not recommended for at least two days before or after a surgery as they may increase the risk of bleeding. Proteolytic enzymes have been shown to be quite helpful in speeding up post-surgical recovery and relieving a complication of surgery and radiation known as lymphedema.

Are proteolytic enzymes actually absorbed?

Yes. One of the outdated arguments against the effectiveness of orally administered proteolytic enzymes was that they either got digested or they were too large to be absorbed. Absorption studies with the various proteolytic enzymes have confirmed that they are absorbed intact. In fact, they appear to be actively transported across the gut wall.3

Since stomach acid can destroy proteolytic enzymes, the best formulas are “enteric coated” – meaning that the pills have a coating around them to prevent the pill from being broken down in the stomach. An enteric-coated pill passes into the small intestine, where due to the pH change it will break down there.

Can taking proteolytic enzymes actually improve digestion?

Yes, in fact, using enzyme preparations to support proper digestive function is used in conventional medicine in cases of pancreatic insufficiency and cystic fibrosis (a rare inherited disorder). Pancreatic insufficiency is characterized by impaired digestion, malabsorption, nutrient deficiencies, and abdominal discomfort.

Do the proteolytic enzymes digest blood proteins?

NO! There are special factors in the blood that block the enzymes so that they do not digest blood proteins.

How do the proteolytic enzymes help autoimmune conditions like rheumatoid arthritis?

The benefits in some inflammatory conditions appears to be related to helping the body breakdown immune complexes formed between antibodies produced by the immune system and the compounds they bind to (antigens). Conditions associated with high levels of immune complexes in the blood are often referred to as “autoimmune diseases” and include such diseases as rheumatoid arthritis, lupus, scleroderma, and multiple sclerosis. Higher levels of circulating immune complexes are also seen in ulcerative colitis, Crohn’s disease, and AIDS.4-6

What other conditions might proteolytic enzymes be helpful for?

The list of conditions benefited by pancreatic enzyme supplementation seems to be growing all the time. For example, one potential use is in the treatment of viral related illness including hepatitis C and herpes simplex infections. For example, in one study in the treatment of herpes zoster (shingles) an orally administered proteolytic enzyme preparation was more effective than the standard drug therapy (acyclovir).8 In a study in patients with hepatitis C, proteolytic enzymes were shown to be slightly superior to alpha-interferon in improving laboratory values and symptoms.9 Proteolytic enzymes also appear to be quite helpful in recovery from surgery, fibrocystic breast disease, acute and chronic sinusitis and bronchitis, and chronic obstructive pulmonary disease and asthma.10-13

What proteolytic enzyme product do you recommend?

In order to get the most out of proteolytic enzymes it is essential to use a high quality product at an adequate dosage. To judge the quality of an enzyme preparation it is important to know what you are looking for. Most of the proteolytic enzymes have well established guidelines developed by the United States Pharmacopoeia (USP) or the Food Chemical Codex (FCC). The product that I recommend contains the following ingredients per enteric-coated tablet. It is more than twice as potent as other popular preparations:

Pancreatin (8X) 200 mg.
Papain (30,000 USP/mg) 120 mg.
Peptizyme SP (200,000 SPU/g) 52 mg.
Bromelain (1,200 MCU/g) 50 mg.

Pancreatin refers to pancreatic enzyme preparations prepared from fresh hog pancreas. The two primary proteases of pancreatin are chymotrypsin and trypsin (also available from ox bile). Papain and bromelain are proteolytic derived from papaya and pineapple, respectively. Peptizyme SP (a special serrapeptase) is derived from a bacteria that resides in the intestines of silk worms. It is also called “silk worm” enzyme as it is the enzyme used to breakdown the cocoon of the silk worm.

The Miracle Enzyme

Dr. Han’s Nieper, a legendary medical doctor known for his extensive use of proteolytic enzymes, called serrapeptase the “Miracle Enzyme.” Dr. Nieper used the enzyme primarily to open up clogged arteries supplying the brain. This enzyme is more powerful than the pancreatic enzymes chymotrypsin and trypsin. It has been used in Europe and Japan for over 25 years. As evident in Table 1, good clinical results have been demonstrated in clinical trials. In addition to its general anti-inflammatory effects, it is particularly beneficial in fibrocystic breast disease as well as upper respiratory tract conditions like sinusitis, bronchitis, asthma, and chronic obstructive pulmonary disease due to its ability to improve the structure and function of the mucus lining.10-13

Table 1. Clinical results from trials with the “Miracle Enzyme”
Condition Cases %
Effectiveness
Post-surgical swelling 742 88.5%
Sports injuries/trauma 208 87.5%
Inflammatory disease 906 77%
COPD/Bronchitis 556 74%
Enhancement of antibiotic 124 79%
ENT infection and inflammation 140 97.3%
Fibrocystic breast disease 70 85.7%

What is the proper dosage of proteolytic enzymes?

The typical dosage for the formula listed above is one to three capsules 10-20 minutes before meals or on an empty stomach when non-digestive effects are desired. If it is being taken for digestive support, then it can be taken just before meals.

Are proteolytic enzymes preparations safe?

Proteolytic enzymes are generally well-tolerated and are not associated with any significant side effects. Even in people with presumably normal pancreatic function, taking proteolytic enzymes produced no untoward side effects nor did it reduce the capacity for these subjects to produce their own pancreatic enzymes.14 However, my recommendation is to utilize these preparations only when there is apparent need.

Although no significant side effects have been noted with any of the proteolytic enzymes, allergic reactions may occur (as with most therapeutic agents). Pancreatic enzymes should not be used by anyone allergic to pork; bromelain should not be used in anyone allergic to pineapple; and papain should not be used in anyone sensitive to papaya.

References:

  1. Gonzalez NJ, Isaacs LL: Evaluation of pancreatic proteolytic enzyme treatment of adenocarcinoma of the pancreas, with nutrition and detoxification support. Nutr Cancer 1999;33:117-24.
  2. Leipner J, Saller R: Systemic enzyme therapy in oncology: effect and mode of action. Drugs. 2000;59:769-80.
  3. Ambrus JL, et al.: Absorption of exogenous and endogenous proteolytic enzymes. Clin Pharmacol Therap 1967;8:362-8.
  4. Mazurov VI, et al. Beneficial effects of concomitant oral enzymes in the treatment of rheumatoid arthritis. Int J Tiss React 1997;19:91.
  5. Ransberger K: Enzyme treatment of immune complex diseases. Arthritis Rheuma 1986;8:16-9.
  6. Steffen C, et al.: Enzyme therapy in comparison with immune complex determinations in chronic polyarteritis. Rheumatologie 1985;44:51-6.
  7. Ransberger K, van Schaik W: Enzyme therapy in multiple sclerosis. Der Kassenarzt 1986;41:42-5.
  8. Kleine MW, et al.: The intestinal absorption of orally administered hydrolytic enzymes and their effects in the treatment of acute herpes zoster as compared with those of oral acyclovir therapy. Phytomedicine 1995;2:7-15.
  9. Kabil SM, Stauder G: Oral enzyme therapy in hepatitis C patients. Int J Tiss React 1997;19:97-8.
  10. Esch PM, Gerngross H, Fabian A: Reduction of postoperative swelling. Objective measurement of swelling of the upper ankle joint in treatment with serrapeptase-a prospective study (German). Fortschr Med. 1989;107(4):67-8, 71-2.
  11. Kee WH, et al.: The treatment of breast engorgement with Serrapeptase (Danzen): a randomized double-blind controlled trial. Singapore Med J 1989;30(1):48-54.
  12. Mazzone A, et al.: Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res 1990; 18(5):379-88.
  13. Majima Y, et al.: The effect of an orally administered proteolytic enzyme on the elasticity and viscosity of nasal mucus. Arch Otorhinolaryngol. 1988;244(6):355-9.
  14. Friess H, et al.: Influence of high-dose pancreatic enzyme treatment on pancreatic function in healthy volunteers. Int J Pancreatol 1998;23:115-23