November 24th, 2015

PQQ Lowers LDL-Cholesterol Levels

lower ldl cholesterolIntroduction

Every major advance in nutritional medicine generally starts out as an unknown entity. That is certainly true for PQQ (short for pyrroloquinoline quinone). Although PQQ is a relatively new dietary supplement on the market, its potential is absolutely enormous. The potential benefits are nearly limitless as it has shown a wide range of enhancements to brain and body function. It is especially powerful in its ability to boost brain function, including memory.

A new study with BioPQQ™ – a safe form of PQQ produced through a natural fermentation process – indicates that it can lower LDL cholesterol levels in subjects with initial levels greater than 140 mg/dl. PQQ is known to activate the enzyme AMP-activated protein kinase (AMPk) that helps to regulate blood lipid levels.

Background Data:

Although PQQ is not currently viewed as a vitamin, it is likely to be considered an essential nutrient in the future. PQQ serves as a cofactor for a special class of enzymes involved in cellular function including cellular growth, development, differentiation, and survival. Without PQQ, our cells would cease to function properly. PQQ has been found in all plant foods analyzed to date. PPQ-rich foods include parsley, green peppers, kiwi fruit, papaya and tofu. These foods contain about 2-3 mcg per 100 grams. Studies with PQQ generally use dosage levels of 10 to 20 mg, which are levels much higher than the typical dietary intake of about 100 mcg.

One key action of PQQ involves a direct action on major enzymes involved in the energy producing compartments in our cells of the mitochondria. As a result, PQQ improves energy production; current research has primarily focused on its ability to protect memory and cognition in both aging animals and humans. Here are some of the effects noted:

  • PQQ reverses cognitive impairment caused by chronic oxidative stress and improve performance on memory tests in animal models.
  • PQQ prevents the development of osteoarthritis in an animal model.
  • PQQ protects nerve cells from the damaging effects of the beta-amyloid-protein linked with Alzheimer’s disease.
  • The combination of PQQ and CoQ10 (respectively, 20 mg and 300 mg) improved mental function in a human double-blind study.
  • PQQ (0.2 mg PQQ/kg body weight) increased the antioxidant potential and energy metabolism while decreasing inflammation in another double-blind study.

New Data:

In this new study, the effects of PQQ (as BioPQQ™) on serum triglyceride and cholesterol levels were examined in humans after 6 and 12 weeks of supplementation at an oral dosage of 20 mg per day. A total of 29 healthy adults, ranging from 40 to 57 years old, with normal to moderately high triglyceride levels (110-300 mg/dL) were included in the study. While the average serum triglyceride levels did not change; in those subjects with LDL-cholesterol levels ≥140 mg/dl), at 6 weeks PQQ supplementation produced a statistically significant decrease in total cholesterol (from an average of 247 to 216 mg/dl) and LDL-cholesterol (from an average of 156 to 132 mg/dl). Results persisted at 12 weeks.

These results show that PQQ supplementation may produce meaningful reductions in LDL-cholesterol presumably as a result of AMPk activation. It adds to a growing body of clinical data on the benefits of this important compound.


PQQ activates AMPk, an enzyme that is found inside every cell that serves as a “master regulating switch” in energy metabolism. Low levels of AMPk activity is associated with:

  • Accelerated aging
  • Chronic inflammation
  • High blood cholesterol and triglycerides
  • Increased visceral “belly” fat
  • Insulin resistance
  • Mitochondrial insufficiency and dysfunction
  • Neurodegeneration
  • Obesity
  • Poor blood sugar control

Since PQQ activates AMPk it is only a matter of time before clinical data is produced showing PQQ is helpful for a long list of health challenges.

Consumers need to be aware of different forms of PQQ on the marketplace. BioPQQ™ is the only form that I know of that is produced naturally. Other forms are produced through a chemical synthesis and involve the use of fairly toxic compounds. Read labels closely and use only BioPQQ™.


Nakano M, Kawasaki Y, Suzuki N, Takara T. Effects of Pyrroloquinoline Quinone Disodium Salt Intake on the Serum Cholesterol Levels of Healthy Japanese Adults.

Dr. Michael Murray

November 17th, 2015

Promoting Satiety is Your Key to Weight Loss

Satiety The Key To Weight LossIntroduction:

The research is quite clear that safe and effective weight loss is not about will power, deprivation, or counting calories. Ultimately, weight loss success is most often attributed to strategies and tools that impact appetite and portion control. In particular, the ability to experience satiety is big factor for success.

Satiety is defined as the state of being full or gratified to the point of satisfaction. Research has shown that humans eat to achieve satiety and those who are overweight have a disordered appetite regulation typified by an increased frequency of food cravings, and a resistance to satiety after eating adequate amounts of food.

New research on promoting satiety with the revolutionary dietary fiber matrix PGX®, once again, establishes it as an extremely effective weight loss tool. In fact, I believe that PGX® is the Holy Grail of weight loss based upon the impressive results it has shown in detailed clinical and experimental studies, including a new study published in the medical journal Physiology & Behaviour on its ability to promote satiety.

Background Data:

PolyGlycoPlex (PGX®) is the most viscous and soluble fiber known. It is produced in a patented process that allows three natural fibers to coalesce and form a matrix that has a higher level of viscosity, gel-forming properties, and has more expansion with water, than any other fiber. In essence, it is a “super” fiber with all of the beneficial effects of fiber, but are magnified and more easily attained with PGX®.

Clinical studies published in major medical journals and presented at the world’s major medical conferences have shown PGX® to exert the following benefits:

  • Increases the level of compounds that block the appetite and promote satiety.
  • Decreases the level of compounds that stimulate overeating.
  • When taken prior to a meal can increase the feeling in fullness, very hungry to very full.
  • It reduces the glycemic index of any food, beverage, or meal by as much as 70%.
  • Increases insulin sensitivity and promotes improved blood sugar control.
  • Helps stabilize blood sugar levels to reduce food cravings.

New Data:

Previous studies have shown that PGX® granules and PGX®-based meal replacement formulas are very effective at promoting satiety leading to a reduction in calories consumed. To test the effects of PGX® capsules, 14 healthy adult women participated in a controlled study. The effects on the level of satiety for 2 hours after eating a standardized evening meal when the PGX® capsules were given was compared to the same meal without PGX®. Also, on the following morning, after an overnight fast, the four hour satiety response to a standardized breakfast with no PGX® supplementation was assessed. This second assessment was designed to measure the “second meal effect” of PGX. The second-meal effect measures the effect the first meal has on the blood sugar level after eating the second meal.

Results showed a statistically significant higher satiety response to the standard dinner for the PGX-supplemented dinner compared with the control dinner (p = 0.001) was found. In addition, the fullness scores of the breakfast following the PGX®-supplemented dinner at 15, 30, 90, 120, 150, 180, 210 and 240 minutes were significantly higher than those for the breakfast following the control dinner. These results show that PGX® supplementation at dinner increased the satiety effects of both the dinner itself and the subsequent un-supplemented breakfast. Hence, PGX® demonstrated a significant second meal effect indicating PGX® has the ability to induce extended satiety far beyond the just the meal it is taken before.


First, if you did not catch it previously, watch my webinar on Preventing Holiday Weight Gain. PGX® can be very helpful in this goal.

In my opinion, PGX® is the most important natural product in North America today because of its ability to address the core underlying reasons why weight loss and blood sugar control are often so difficult to achieve. Yes, I played a role in the development of PGX®, so some may say that I am severely biased. My response is that I am biased, but it is not because of any financial benefit. My bias is a reflection of the powerful effect that I have seen this safe and effective natural product have on changing people’s lives. I want everyone who has struggled with weight loss to give PGX a try. My hope is that it will change your life, as it has changed the lives of so many others. It works!!

For more information on PGX and practical guidelines to insure weight loss success, please go to


Yong MK, Solah VA, Johnson SK, et al. Effects of a viscous-fibre supplemented evening meal and the following un- supplemented breakfast on post-prandial satiety responses in healthy women, Physiology & Behavior 2015:doi 10.1016/j.physbeh.2015.11.006 [Epub ahead of print]

Dr. Michael Murray

November 10th, 2015

Resveratrol Shows Beneficial Effects in Ulcerative Colitis

Ulcerative Colitis TreatmentIntroduction:
Resveratrol is a plant compound similar to flavonoids. It is found in the low levels of the skin of red grapes, red wine, cocoa powder, baking chocolate, dark chocolate, peanuts and mulberry skin. Red wine is perhaps the most recognized source of resveratrol, however, red wine contains only one milligram per glass. Most resveratrol supplements use Japanese knotweed (Polygonum cuspidatum) as the source.

There has been a great deal of hype regarding resveratrol as a dietary supplement and recent human clinical studies are showing tremendous promise in a variety of applications. A study published in the May issue of the Archives of Medical Research indicates that it can help patients with ulcerative colitis.

Background Data:
Inflammatory bowel disease (IBD) is a general term for a group of chronic inflammatory disorders of the intestines. It is divided into two major categories: Crohn’s disease (CD) and ulcerative colitis (UC). Clinically, IBD is characterized by recurrent inflammation of specific intestinal segments resulting in diverse symptoms. In the United States, about 1.4 million people have IBD with the number equally split between CD and UC. IBD may occur at any age, but it most often occurs between the ages of 15 and 35 years. Females are affected slightly more frequently than males. Caucasians have the disease two to five times more often than African or Asian Americans, and those with a Jewish heritage have a three-fold to six-fold higher incidence than non Jewish people.

One of the thoughts is that UC develops by a defect in the regulation of the immune response to intestinal flora in genetically susceptible individuals. Of course, the gut flora and intestinal environment is greatly influenced by dietary factors including low-fiber intake, reduced intake of dietary anti-inflammatory compounds such as flavonoids and omega-3 fatty acids, and increased intake of refined carbohydrates. Several studies that analyzed the pre-illness diet of patients with IBD have found that they habitually ate more refined sugar, chemically modified fats, processed and fast foods, and meat, while consuming less raw fruit, vegetables, omega-3 fatty acids and dietary fiber than healthy people.

The main drug approach in UC is the use of anti-inflammatory agents, corticosteroids like Prednisone, immune system modulators and antibiotics. These drugs are only palliative and offer no real path to complete resolution.

Resveratrol exerts a wide range of anti-inflammatory effects indicating a possible benefit in UC. In animal models of UC, resveratrol improved the disease activity index and decreased oxidative stress and inflammatory biomarkers.

New Data:
In a study sponsored by the National Nutrition and Food Technology of Iran, researchers sought to evaluate the effects of supplementation with resveratrol on inflammation and quality of life in patients with active UC in a double-blind, placebo-controlled format. The 50 eligible patients with active mild to moderate UC were given either 500 mg of resveratrol or a placebo capsule for 6 weeks. Serum inflammatory markers and quality of life assessments were conducted at baseline and at the end of the study.

Results showed that resveratrol supplementation led to a significant reduction in plasma levels of key inflammatory markers. Specifically, in the resveratrol group, the level of tumor necrosis factor-alpha (TNF-α), highly sensitive C-reactive protein (hs-CRP) and nuclear factor kappa-B (NF-κB) all showed statistically significant reductions. In contrast, no change was seen in the placebo group. Clinical evaluation also indicated a significant drop in the Clinical Colitis Activity Index Score decreased significantly in the resveratrol group, when compared with the placebo group.

The researchers concluded, “6 weeks supplementation with 500 mg resveratrol can improve quality of life and disease clinical colitis activity at least partially through inflammation reduction in patients with UC.”

Based upon the use of resveratrol for other applications, I question if a higher dosage (e.g., 500 mg two to three times daily) might have brought about even better results.

In addition to general measures to improve inflammatory bowel disease (IBD), I think the first step is an allergy elimination diet to address possible food allergies. In regards to nutritional supplementation, a broad-based nutritional supplementation plan is necessary for all patients with IBD. Particularly important are the nutrients zinc, folic acid, vitamin B12, magnesium, vitamin A, and vitamin D. Nutritional supplements are used as appropriate to correct deficiencies, normalize the inflammatory process, and promote healing of the damaged mucosa. Botanical medicines, including flavonoid-rich extracts or resveratrol, can be used to promote healing and normalize the intestinal flora.

Here are the key supplements that I recommend for IBD:
• High potency multivitamin and mineral supplement.
• Zinc picolinate: 15 mg/day in addition to the 15 to 30 mg in a high potency multiple
• Vitamin C: 500 to 1,000 mg daily
• Vitamin D: 2,000 to 5,000 IU daily
• Fish oil: 3,000 mg EPA+DHA daily
• Choose one of the following:
o Grape seed extract (>95% procyanidolic oligomers): 150 to 300 mg daily (or 1-2 mg per kg [2.2 pounds] body weight)
o Pine bark extract (>90% procyanidolic oligomers): 150 to 300 mg daily (or 1-2 mg per kg [2.2 pounds] body weight)
o Green tea extract (>90 polyphenol content): 300 to 450 mg daily
o Resveratrol: 500 mg two to three times daily.
• Probiotic supplement (providing various Lactobacillus and Bifidobacter sp.): minimum of 5 to 12 billion colony forming units daily
• Prebiotics (PGX®, inulin, fructose oligosaccharides, etc.): 5 g per day

Samsami-Kor M, Daryani NE, Asl PR, Hekmatdoost A. Anti-Inflammatory Effects of Resveratrol in Patients with Ulcerative Colitis: A Randomized, Double-Blind, Placebo-controlled Pilot Study. Arch Med Res. 2015 May;46(4):280-5.

Dr. Michael Murray