Ultra Clean TMG Trimethylglycine — 600mg — 60 Vegan Capsules

TMG provides 600 mg of trimethylglycine, also known as anhydrous betaine, in each capsule. As a methyl donor and cellular osmolyte, TMG supports healthy homocysteine metabolism, efficient methylation, SAMe production and cellular hydration—functions that help explain its growing use in healthy-aging and active-lifestyle programs.*

Focused methylation and homocysteine support

TMG is a naturally occurring compound related to the amino acid glycine. Its structure contains three methyl groups, making it an important methyl donor in the body. Methylation is involved in many essential functions, including normal cellular regulation, neurotransmitter metabolism and the production of numerous biological compounds. Each capsule supplies 600 mg of pure anhydrous betaine for targeted daily methylation support.*

Why TMG is gaining attention in healthy aging

TMG donates a methyl group through the betaine-homocysteine methyltransferase pathway, helping convert homocysteine back into methionine and supporting production of S-adenosylmethionine (SAMe). These methylation pathways help maintain normal cellular regulation and complement folate, vitamin B12 and vitamin B6. TMG has also attracted interest among users of NAD+ precursors because nicotinamide metabolism can consume methyl groups. This biochemical rationale supports TMG's popularity in healthy-aging programs, but it should not be interpreted as evidence that TMG extends lifespan or reverses biological aging.*

Potential support for exercise performance

In addition to serving as a methyl donor, TMG functions as an osmolyte—a compound that helps cells maintain normal hydration and protein stability during physical stress. Its methyl-donor activity also supports pathways involved in the body's production of creatine. Human studies have reported possible benefits for selected measures of power, training volume and body composition, although findings are mixed. Most performance studies used approximately 2.5 grams daily, which is higher than this product's suggested 600- to 1,200-mg daily intake; therefore, those outcomes should not be assumed at the labeled dose.*

Methylation, creatine and cellular energy pathways

Methionine produced through normal homocysteine metabolism can be used to form SAMe, a major methyl donor throughout the body. Methyl groups are also used in endogenous creatine synthesis, a process connected to normal cellular energy metabolism. By supplying readily available methyl groups, TMG helps support these fundamental metabolic pathways without replacing a balanced diet, exercise program or other essential nutrients.*

Simple and flexible daily use

TMG is designed for adults who want a straightforward way to add trimethylglycine to their daily wellness routine. Each capsule provides a clearly defined 600 mg serving. Take one capsule once or twice daily, or as directed by your healthcare provider. The 60-capsule bottle provides a 60-day supply when taken once daily or a 30-day supply when taken twice daily.

Key Benefits and Features

• Supports the healthy conversion of homocysteine to methionine.*
• Provides methyl groups that support SAMe availability.*
• Supports methylation pathways associated with healthy aging.*
• Functions as an osmolyte to support normal cellular hydration.*
• Supports pathways involved in creatine and cellular energy metabolism.*
• Supplies 600 mg of trimethylglycine as anhydrous betaine per capsule.
• Provides flexible once- or twice-daily dosing.
• Made with a vegan hydroxypropyl methylcellulose capsule.

Why Choose Us

• Manufactured in a USA cGMP facility.
• Made with carefully selected, science-backed ingredients.
• Third-party tested for quality and purity.
• Clean formulation with no artificial colors or flavors.
• Personally formulated and developed by Dr. Michael T. Murray.