June 11th, 2012

Theracurmin™

Curcumin is one of the most intensely studied natural products. Preclinical research has indicated a long list of possible uses due to its ability to switch off inflammation in an unparalleled manner. Unfortunately, clinical research has been limited due to curcumin’s poor absorption in humans. Theracurmin is the most bioavailable form of curcumin. In this informative presentation Dr. Murray provides an overview on why there is so much excitement at major research centers and universities about Theracurmin. According to Dr. Murray, Theracurmin is a “Game Changer” – watch the video and learn why.

Antioxidant and anti-inflammatory protection in a more bioavailable form than ever before

Theracurmin is a special advanced form of curcumin—the yellow pigment of turmeric (Curcuma longa), the chief ingredient in curry. Curcumin has demonstrated significant activity in many experimental and clinical studies, but its effects have been limited until now because of poor absorption. Theracurmin is by far the most bioavailable form of curcumin and represents a major breakthrough in the use of curcumin to promote health. Many of curcumin’s beneficial effects are attributed to its antioxidant and anti-inflammatory effects.

Special Effects of Curcumin

What research has continually documented is that curcumin is highly pleiotropic, meaning it exerts multiple actions. Foremost is curcumin’s ability to act as an antioxidant and influence many factors involved when normal inflammatory processes get out of balance. Curcumin has demonstrated significant anti-inflammatory activity in a variety of experimental models as well as clinical studies. In these studies, curcumin’s anti-inflammatory effects have been shown to be comparable to the potent drugs hydrocortisone and phenylbutazone, as well as over-the-counter anti-inflammatory agents, such as ibuprofen.

Curcumin has also demonstrated significant effects in preventing the accumulation of compounds associated with premature aging. For example, beta-amyloid is a compound linked to aging in the brain and the development of Alzheimer’s disease. It is essentially a biochemical scar in brain tissue that reflects damage due to inflammation. Curcumin is showing great promise in preserving brain health by preventing the accumulation of beta-amyloid. However, in order for this benefit to be realized, it must first be absorbed.

Enhancing the Benefits of Curcumin

While many preliminary studies show curcumin has great promise, a major issue limiting its clinical use has been that it is not very well absorbed. Several types of curcumin products have now been developed to more effectively raise blood and tissue levels of curcumin. Theracurmin is by far the most advanced of these techniques. This all-natural preparation reduces the particle size of curcumin, while dramatically increasing its solubility. The average particle size of typical curcumin is 22.75 μm. In Theracurmin, the particle size has been reduced to 0.19 to 0.3 μm—a reduction of over 100 times. This reduced particle size curcumin is then mixed with natural emulsifiers to suspend it in a highly bioavailable mixture that is then dried. The result of all of this technology is a dramatic increase in the absorption of curcumin as compared to all other commercial forms that have been tested, including other enhanced forms of curcumin.

 Theracurmin Increases “Free” Curcumin

In addition to being poorly absorbed, regular curcumin is rapidly metabolized in the liver. When measuring levels of curcumin in the blood during absorption studies, the value of curcumin is based upon total curcuminoids, including metabolites. The only product form that has shown to actually increase the free curcumin form is Theracurmin. Since free curcumin is significantly more active than the metabolites, it is extremely likely that Theracurmin is not only better absorbed, but it also produces additional benefits as compared to other supplemental forms of curcumin.

Health Benefits of Theracurmin

Because Theracurmin enhances the absorption of curcumin, all of the benefits associated with curcumin are also enhanced. Theracurmin has been the subject of several clinical studies that have shown Theracurmin possesses an ability to reduce tissue damage caused by inflammation, improve liver function, increase the ability of the heart to function more efficiently, and increase the flexibility of the arteries. Currently, Theracurmin is being investigated for additional properties at some of the major universities and research centers in the world. The dosage recommendation of Theracurmin, based upon the existing clinical evaluation, is 300 to 600 mg per day.

Theracurmin is the Most Bioavailable Form of Curcumin

The above graph demonstrates Theracurmin is by far the most bioavailable form of curcumin. Theracurmin is the only curcumin preparation currently available that produces a clear dose response. What that means is that even small dosages of Theracurmin increase blood measurements of curcumin, and, as the dosage increases, so does the blood level. This increase is linear, meaning that it increases in the blood in a parallel fashion to the dosage. This absorption profile is extremely important; as the effectiveness of curcumin within the body requires achieving effective concentrations. Theracurmin is able to achieve necessary concentrations within the body that are not likely to be easily achieved, if at all, with other curcumin preparations.

A short video showing the amazing dissolution of Theracurmin in water compared to regular curcumin powder. This dramatic dispersion in water translates to the dramatic increases in bioavailability seen with Theracurmin.

Possible Interactions with Chemotherapy Agents

Curcumin has been shown to enhance the sensitivity of cancer cells to most chemotherapy agents. It also has been shown to protect against chemotherapy-induced damage to heart and other tissues. However, may interfere with the effects of some chemotherapy agents based upon studies in cell cultures. Although the clinical significance of this interaction is not known, I recommend anyone taking the following drugs to be sure and check with their physician before taking any curcumin product:

  • Camptothecin
  • Mechlorethamine
  • Doxorubicin
  • Cyclophosphamide
  • Norfloxacin

References:

Theracurmin Human Absorption Study #1

Theracurmin Human Absorption Study #2

Theracurmin Improves Arterial Function in Postmenopausal Women

Theracurmin Review – Improves Congestive Heart Failure – Most Bioavailable Form of Curcumin