December 1st, 2013

Theracurmin Reduces Exercise-Induced Oxidative Stress

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Introduction

Theracurmin is a special advanced form of curcumin – the yellow pigment of turmeric (Curcuma longa) – the chief ingredient in curry. Curcumin has demonstrated significant activity in many experimental and clinical studies, but its effects have been limited until now because of poor absorption. Theracurmin is by far the most bioavailable form of curcumin and represents a major breakthrough in the use of curcumin to promote health. Many of curcumin’s beneficial effects are attributed to its ability to act as an antioxidant and help to restore balance in certain cellular functions. New data shows that these benefits are most easily achieved by using Theracurmin.

Background Data:
Exercise produces many beneficial effects. However, it can also lead to an increase in reactive oxygen species (ROS) that can damage DNA, proteins and lipids. Exercise can increase oxygen utilization 200-fold above resting levels in active muscles and lead to the generation of considerable ROS. There is a strong link between oxidative stress and fatigue as well as muscle damage, which cannot only affect exercise performance, but also cellular health.

In previous studies, Theracurmin was shown to produce significant benefits in improving heart and vascular function in subjects with congestive heart failure as well as dramatically enhance the benefits of exercise on improving the health of the aorta and the entire arterial system.

New Data:
In a study conducted by the Department of Sport Sciences, Waseda University, in Japan, curcumin as Theracurmin was shown to reduce oxidative stress and increase the antioxidant capacity in response to acute endurance exercise in humans. In the study, 10 male participants, ages 26.8±2.0 years, completed 3 trials in a random order: (1) placebo (control), (2) single (only before exercise) and (3) double (before and immediately after exercise) curcumin supplementation trials. Each participant received oral administration of 90 mg of curcumin (from 900 mg Theracurmin) or the placebo 2 hours before exercise and immediately after exercise.

Each participant walked or ran at 65% of VO2 max on a treadmill for 60min. Blood samples were collected pre-exercise, immediately after exercise and 2 hours after exercise. The concentrations of serum derivatives of reactive oxygen metabolites measured immediately after exercise were significantly higher than pre-exercise values in the placebo trial (308.8), but not in the single (259.9) or double (273.6) curcumin supplementation trials. Serum biological antioxidant potential concentrations measured immediately after exercise were significantly elevated in the single and double curcumin supplementation trials compared with pre-exercise values (P<0.05).

These findings indicate that curcumin supplementation can reduce exercise-induced oxidative stress by increasing blood antioxidant capacity.

Blood measurements of curcumin once again showed excellent absorption with Theracurmin and a clear dose response. The plasma curcumin concentrations in the double curcumin supplementation trial 2 hours after exercise were significantly higher than those in the single curcumin supplementation trial.

Commentary:
Theracurmin is the most bioavailable form of curcumin capable of increasing blood levels of curcumin significantly greater than other forms of curcumin including other forms claiming enhanced absorption. Detailed studies have shown that Theracurmin is:

  • The most bioavailable form of curcumin.
  • A colloidal mixture produced by reducing the particle size of curcumin by over 100 times and emulsified with a natural vegetable gum.
  • The only product form that has shown to produce a clear dose response.
  • Extremely safe and clinically tested.

For more information, click here.

Reference:
Takahashi M, Suzuki K, Kim HK, et al. Effects of Curcumin Supplementation on Exercise-Induced Oxidative Stress in Humans. Int J Sports Med. 2013;34:1-7.