In a very detailed analysis published in the online version of Frontiers in Neurology, researchers painstakingly reviewed the evidence from clinical trials and pre-clinical investigations on the association with PPI use with dementia and depression in the elderly and impaired cognitive function and depression in younger adults. What their results showed was:
“The findings of most research studies described above indicate that there is a direct association between the onset of dementia and depression on one side and the long-term use of PPIs on the other.”
The researchers provided a warning signal to doctors and pharmacists not only on the adverse effects of these drugs on the elderly, but also in younger adults as well. There is growing concern that these drugs depress cognition and mood in all ages. It is just that the elderly seem to be hit the hardest. However, the researchers demonstrated that even in younger adults detailed double-blind studies exist that indicate significant negative impact of these drugs in the ability to think clearly and be happy.
The author’s of the study encouraged physicians to look more critical at the risks vs. benefits of PPIs.
The findings of the review of the data are not surprising. The research is just that obvious. Where this analysis misses the mark is failing to provide a safe, natural alternative to PPIs. This topic was dealt with in a previous newsletter. So, if you are interested in how to deal with GERD and get off PPIs by using a natural approach simply click here. Head-to-head studies with this natural solution against other drugs, including PPIs, other acid-blocking drugs, and antacids have shown this natural approach is superior to others in terms of safety and efficacy. The effects are immediate and long-lasting. And, no side effects, drug interactions, or toxicity exist with this natural solution.
Novotny M, Klimova B, Valis M. PPI Long Term Use: Risk of Neurological Adverse Events? Front Neurol. 2019 Jan 8;9:1142. doi: 10.3389/fneur.2018.01142